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Crit Rev Eukaryot Gene Expr. 1992;2(4):283-314.

The nuclear serine/threonine protein kinase DNA-PK.

Author information

1
Biology Department, Brookhaven National Laboratory, Upton, NY 11973.

Abstract

The DNA-activated protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase that phosphorylates DNA-binding proteins, including several transcription factors. DNA-PK is one of a very few enzymes known to be regulated through interaction with DNA that does not have DNA as a template or substrate. We suggest that DNA-PK may function in cell homeostasis, in part through the modulation of transcriptional activity.

PMID:
1486241
[Indexed for MEDLINE]

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