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Curr Opin Cell Biol. 1992 Dec;4(6):975-8.

Determinants of mRNA localization.

Author information

1
University of Massachusetts, Department of Cell Biology, Worcester 01655.

Abstract

RNA localization provides a mechanism for protein targeting within developing or differentiating cells. Specific cis-acting sequences on mRNA mediate this process. Such 'localizer' or 'zipcode' nucleic acid sequences have been restricted to the 3' untranslated region of several mRNAs. The presence of genetic information denoting a spatial component of translation adds a new dimension to gene expression.

PMID:
1485968
DOI:
10.1016/0955-0674(92)90128-y
[Indexed for MEDLINE]

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