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Brain Res Dev Brain Res. 1992 Dec 18;70(2):287-90.

A narrow window of intracellular calcium concentration is optimal for neurite outgrowth in rat sensory neurones.

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1
Department of Physiology, University College London, UK.

Abstract

We have examined neurite outgrowth in rat sensory neurones when cytosolic free calcium concentration ([Ca2+]i) was varied in the range 0-60 nM. Neurite outgrowth was maximal at 35 nM [Ca2+]i and was reduced at higher and lower values of [Ca2+]i. These results provide direct evidence for Mattson and Kater's suggestion of an optimal calcium range for growth cone function.

PMID:
1477964
[Indexed for MEDLINE]
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