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Curr Opin Genet Dev. 1992 Dec;2(6):907-12.

Position effect and related phenomena.

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Fred Hutchinson Cancer Research Center, Seattle, Washington.


Position-effect variegation in Drosophila, the mosaic expression of genes juxtaposed to heterochromatin, remains an enigmatic long-range phenomenon. While the chromatin-conformation model has been challenged, compelling contrary evidence is lacking. Nevertheless, progress has been made in the genetic and molecular analysis of genes involved in the process of heterochromatin formation and in the characterization of genetic elements normally located in pericentric heterochromatin. In addition, telomeric position effect in yeast provides a new model system for the study of the quasi-stable inheritance of an inactivated state.

[Indexed for MEDLINE]

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