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Cell Mol Life Sci. 2004 Feb;61(3):292-300.

Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D.

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  • 1Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Abstract

The semaphorin proteins were identified originally as axonal guidance factors functioning during neuronal development. In addition to this function, several semaphorins play diverse roles outside the nervous system. The class 4 semaphorin CD100/Sema4D, which utilizes plexin-B1 and CD72 as receptors, exerts important biological effects on a variety of cells, including the neuronal, epithelial and immune cells. Here, we review recent advances exploring the molecular mechanisms governing the biological functions of CD100/Sema4D.

PMID:
14770294
DOI:
10.1007/s00018-003-3257-7
[PubMed - indexed for MEDLINE]
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