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Diabetologia. 2004 Mar;47(3):581-589. doi: 10.1007/s00125-004-1336-4. Epub 2004 Feb 7.

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.

Author information

1
Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, 8091, Zurich, Switzerland. marc.donath@usz.ch.
2
Department of Genetic Medicine and Development, University Medical Centre, Geneva, Switzerland.

Abstract

Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or relative insulin insufficiency in both conditions. In this For Debate, we consider the possible mechanisms responsible for beta-cell death and impaired function and their relative contribution to insulin insufficiency in diabetes. Beta-cell apoptosis and impaired proliferation consequent to hyperglycaemia is one pathway that could be operating in all forms of diabetes. Autoimmunity and other routes to beta-cell death are also considered. Recognition of decreased functional beta-cell mass and its overlapping multifactorial aetiology in diabetic states, leads us to propose a unifying classification of diabetes.

PMID:
14767595
DOI:
10.1007/s00125-004-1336-4
[Indexed for MEDLINE]

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