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Immunol Today. 1992 Nov;13(11):441-4.

The cognitive principle challenges clonal selection.

Author information

1
Dept of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Abstract

Here, Irun Cohen argues that the clonal selection paradigm is no longer a convenient paradigm for organizing thinking about the immune system. He contends that most immunologists now investigate questions for which the clonal selection paradigm makes no provision and that one of its major tenets is contradicted by the prevalence of natural autoimmunity. Instead, he proposes a cognitive paradigm.

PMID:
1476598
DOI:
10.1016/0167-5699(92)90071-E
[Indexed for MEDLINE]

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