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Eur J Biochem. 2004 Feb;271(4):780-4.

A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum.

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  • 1Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University of Jerusalem, Israel.


A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

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