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Curr Opin Investig Drugs. 2003 Dec;4(12):1442-50.

Decitabine: development of a DNA methyltransferase inhibitor for hematological malignancies.

Author information

1
jlyons1@ireland.com

Abstract

Decitabine (DAC) is a small molecule nucleotide analog that is incorporated into DNA and traps human DNA methyltransferases. Although initially developed as a cytotoxic agent, low-dose DAC is enjoying a revival as a specific inhibitor of hypermethylation in cancer. DAC has activity in several hematological diseases, especially myelodysplastic syndrome, chronic myelogenous leukemia and acute myeloid leukemia. Clinical and preclinical advances are presented in this review.

PMID:
14763130
[Indexed for MEDLINE]

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