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Rev Hosp Clin Fac Med Sao Paulo. 2003 Nov-Dec;58(6):315-9. Epub 2004 Jan 28.

Prevalence of antinuclear autoantibodies in the serum of normal blood dornors.

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1
Department of Dermatology, Immunopathology Laboratory, Hospital das Cl nicas, University of S o Paulo, S o Paulo, SP, Brazil.

Abstract

OBJECTIVE:

To examine the presence of serum antinuclear autoantibodies in a healthy population.

METHODS:

Serum of 500 normal blood donors between 18 and 60 years of age were tested for the presence of autoantibodies. Antinuclear antibodies were detected by indirect immunofluorescence technique using HEp-2 epithelial cells as the substrate. The presence of dnaN was detected by indirect immunofluorescence technique using Critidia lucillae as the substrate. Anti-SSA (RO), anti-SSB (LA), anti-Sm, and anti-RNP were determined by double radial immunodiffusion.

RESULTS:

In the evaluation of the presence of serum antibodies, antinuclear antibodies were detected in 22.6% of the sera. The presence of other antibodies was not significant. The majority of the titers were 1:40.

CONCLUSION:

The presence of autoantibodies is not necessarily pathologic and has to be related to the age group, gender, and clinical condition of the patient.

PMID:
14762490
[Indexed for MEDLINE]
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