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Arch Pediatr. 2004 Feb;11(2):99-107.

[Vincristine treatment for function- and life-threatening infantile hemangioma].

[Article in French]

Author information

1
Consultation des angiomes, hôpital Lariboisière, AP-HP, 75010 Paris, France. odile.enjolras@lrb.ap-hop-paris.fr

Abstract

AIM:

To evaluate the efficacy of vincristine treatment for function- and life-threatening hemangiomas.

PATIENTS AND METHOD:

Nine infants, eight girls and one boy, received vincristine treatment (VCR) for endangering hemangiomas. In six cases, the hemangiomas involved head and neck in a segmental unilateral or bilateral distribution (3/6 also had laryngeal and 2/6 tracheal location causing respiratory distress, 5/6 had eyelid and orbital involvement); one infant had disseminated neonatal hemangiomatosis (skin, liver, kidney); two infants had liver hemangiomas with cardiac failure. VCR was prescribed after failure of high-dosage corticosteroid treatment in six, and of both corticosteroids and interferon alpha 2b (5 months) in one; two infants received VCR as first line treatment.

RESULTS:

A dosage of 1 mg/m(2) IV injection was delivered, with weekly injections first, and then tapering, increasing the interval between injections, depending on the clinical response. The nine infants received from 5 to 25 injections (average: 16), for a length of treatment of 1.5-8 months (average: 5.5 months). In seven patients a clear clinical response was observed at the end of the first month of treatment, while a slow protracted response was noted in two. Transient mild side effects were present in four patients.

DISCUSSION:

Corticosteroid treatment, although a worldwide recognized treatment of problematic hemangiomas, cannot always control the growth of alarming hemangiomas. Interferon alpha 2a and 2b have proven a 90% effectiveness: treatment for cortico-resistant, function- and life-threatening, hemangiomas.

PMID:
14761730
DOI:
10.1016/j.arcped.2003.10.014
[Indexed for MEDLINE]

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