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Zhonghua Gan Zang Bing Za Zhi. 2004 Jan;12(1):16-7.

[Evaluation of the reliability of three different hepatitis E diagnosis reagents on the clinical acute hepatitis E].

[Article in Chinese]

Author information

1
The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China.

Abstract

OBJECTIVE:

To evaluate the reliability of different hepatitis E diagnosis reagent tests on the acute hepatitis E.

METHODS:

Three acute hepatitis E diagnosis tests, E2-IgM (Wantai, China), GL-IgM and GL-IgG (Genelabs, Singapore) were compared for their reliability in a sera panel composed by 273 healthy individuals and 525 hepatitis.

RESULTS:

The specificity of E2-IgM on the diagnosis of acute hepatitis E was 100.0%, it was significantly higher than GL-IgM (96.7%) and GL-IgG (85.4%). The sensitivity of E2-IgM and GL-IgG were 97.9% and 93.8% respectively, both significantly higher than GL-IgM (72.9%). Among 65 acute hepatitis cases being positive on GL-IgM test but negative on E2-IgM, 58 (89.2%) cases were found to be positive with anti-hepatitis A virus IgM, it indicated that the GL-IgM test might be interfered by other IgM antibodies on serum.

CONCLUSION:

E2-IgM is a good test for the diagnosis of acute hepatitis E.

PMID:
14761275
[Indexed for MEDLINE]

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