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Br J Cancer. 2004 Feb 9;90(3):701-4.

Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas.

Author information

1
Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.

Abstract

Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.

PMID:
14760387
PMCID:
PMC2409590
DOI:
10.1038/sj.bjc.6601584
[Indexed for MEDLINE]
Free PMC Article

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