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Trends Genet. 1992 Oct;8(10):341-4.

Insertional mutation of 'classical' and novel genes in transgenic mice.

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1
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618.

Abstract

Approximately 5% of established transgenic lines carry insertional mutations. The mutated genes may be directly isolated using the transgene DNA as a molecular probe. These mutants provide useful models of human inherited disorders and developmental abnormalities.

PMID:
1475845
[Indexed for MEDLINE]
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