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J Cell Biol. 2004 Feb 2;164(3):347-51.

Cleavage furrow positioning.

Author information

1
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. mglotzer@imp.univie.ac.at

Abstract

To complete the cell cycle, the cleavage furrow draws the plasma membrane toward the cell center, pinching the cytoplasm into two lobes that are subsequently separated into two cells. The position of the cleavage furrow is induced by the mitotic spindle during early anaphase. Although the mechanism of cleavage furrow positioning is not understood at a molecular level, recent results suggest that it might be mediated by local relief from the inhibitory effects of microtubules.

PMID:
14757750
PMCID:
PMC2172245
DOI:
10.1083/jcb.200310112
[Indexed for MEDLINE]
Free PMC Article

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