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Diagn Cytopathol. 2004 Feb;30(2):122-4.

Mixed follicular-medullary thyroid carcinoma: a case report.

Author information

1
Endocrine Institute, Haemek Medical Center, Afula, Israel. Luboshitzky_r@clalit.org.il

Abstract

We report on a 35-yr-old woman presenting with a single thyroid nodule. Fine-needle aspiration (FNA) of the nodule was reported to contain both follicular and parafollicular cells. The biphasic nature of the tumor was highlighted on immunohistochemical investigation of the cellblock. Positive staining for thyroglobulin was limited to the follicular structures and the dense areas stained positive for calcitonin. The serum calcitonin level was highly elevated. Surgery was recommended because of suspected malignancy. The patient underwent total thyroidectomy. The diagnosis of mixed medullary and follicular carcinoma of the thyroid was established by histological investigation using immunohistochemical staining for thyroglobulin, chromogranin, and calcitonin. The patient was well 1 yr after the operation. Repeated measurements of serum calcitonin levels were normal. Total body scan revealed no radioactive iodine uptake in the thyroid bed, bones, or lungs.

PMID:
14755766
DOI:
10.1002/dc.20010
[Indexed for MEDLINE]

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