Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2004 Feb;113(3):340-5.

Central role of the P2Y12 receptor in platelet activation.

Author information

  • 1Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA.

Abstract

Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.

PMID:
14755328
PMCID:
PMC324551
DOI:
10.1172/JCI20986
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Journal of Clinical Investigation Icon for PubMed Central
    Loading ...
    Support Center