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Pediatr Blood Cancer. 2004 Jan;42(1):36-40.

Immune responses to influenza immunization in children receiving maintenance chemotherapy for acute lymphoblastic leukemia.

Author information

1
Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Colorado Health Sciences Center, Denver, Colarado 80218, USA. porter.christopher@tchden.org

Abstract

PURPOSE:

To compare the immune responses to influenza vaccine in children with acute lymphoblastic leukemia (ALL) receiving maintenance chemotherapy with those in healthy children.

METHODS:

Hemagglutinin-inhibition (HAI) antibody titers were determined before and after influenza vaccination in children with ALL and healthy controls. Immune responses were measured as geometric mean titers (GMT) and 4-fold rises in HAI titers.

RESULTS:

Although post-immunization GMT were lower in children with ALL compared to healthy children for the H1N1 antigen (P<0.001), the H3N2 antigen (P=0.03), and for the influenza B antigen (P=0.003), at least 60% of children with ALL had at least a 4-fold rise in HAI titers to each of the influenza antigens.

CONCLUSIONS:

While the GMT after trivalent influenza immunization in children with ALL were significantly lower than those seen in healthy children, the majority of children with ALL had 4-fold rises in HAI titers. Children receiving maintenance chemotherapy for ALL should receive yearly influenza vaccine.

PMID:
14752792
DOI:
10.1002/pbc.10459
[Indexed for MEDLINE]

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