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Semin Immunol. 2004 Feb;16(1):43-53.

Sensing infection in Drosophila: Toll and beyond.

Author information

1
UPR 9022 du CNRS, Institut de Biologie Mol├ęculaire et Cellulaire, 15, rue R. Descartes, F67084 Strasbourg Cedex, France. D.Ferrandon@ibmc.u-strasbg.fr

Abstract

Drosophila has evolved a potent immune system that is somewhat adapted to the nature of infections through the selective activation of either one of two NF-kappa B-like signalling pathways, the Toll and IMD (Immune deficiency) pathways. In contrast to the mammalian system, the Toll receptor does not act as a pattern recognition receptor (PRR) but as a cytokine receptor. The sensing of microbial infections is achieved by at least four PRRs that belong to two distinct families: the peptidoglycan recognition proteins (PGRPs) and the Gram-negative binding proteins (GNBPs)/beta-glucan recognition proteins (beta GRPs).

PMID:
14751763
DOI:
10.1016/j.smim.2003.10.008
[Indexed for MEDLINE]

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