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Semin Immunol. 2004 Feb;16(1):35-41.

The role of Toll-like receptors in combating mycobacteria.

Author information

1
Department of Microbiology and Immunology, Division of Dermatology, 52-121 CHS, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. skrutzik@ucla.edu

Abstract

In the battle against infections with mycobacteria, the body employs components of both the innate and adaptive arms of the immune system. Toll-like receptors (TLRs) mediate the activation of cells of the innate immune system leading to dynamic functions including direct anti-microbial activity, induction of cytokine secretion, triggering dendritic cell maturation, and triggering apoptosis. Furthermore, TLR activation is capable of modulating the adaptive immune response with a bias towards a Th1 T-cell response. However, the activation of TLRs by mycobacteria may also provide a means of immune evasion. Therefore, the modulation of TLR activation can influence the ability to properly destroy invading pathogens such as mycobacteria.

PMID:
14751762
DOI:
10.1016/j.smim.2003.10.005
[Indexed for MEDLINE]

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