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Pharmacol Biochem Behav. 2004 Feb;77(2):399-404.

Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis.

Author information

1
Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmacia y Bioquímica, Junín 956 (1113), Buenos Aires, Argentina.

Abstract

We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of HN. The present paper reports the identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). These effects should be taken into account when considering the pharmacological actions of valeriana extracts.

PMID:
14751470
[Indexed for MEDLINE]

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