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Farmaco. 2004 Jan;59(1):33-9.

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

Author information

1
Dipartimento Farmaco-Chimico, UniversitĂ  di Messina, viale Annunziata, 98168, Messina, Italy.

Abstract

Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

PMID:
14751314
DOI:
10.1016/j.farmac.2003.09.001
[Indexed for MEDLINE]

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