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Int J Cancer. 2004 Mar 20;109(2):157-62.

Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins.

Author information

1
Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA. duensing@pitt.edu

Abstract

Genomic instability is a hallmark of most human cancers including high-risk human papillomavirus (HPV)-associated anogenital neoplasia. The two HPV-encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV-induced genomic instability and discuss its significance in the context of human carcinogenesis.

PMID:
14750163
DOI:
10.1002/ijc.11691
[Indexed for MEDLINE]
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