Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 2004 Jan;190(1):275-80.

Three-dimensional sonographic measurement of normal fetal brain volume during the second half of pregnancy.

Author information

1
Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. n.roelfsema@erasmusmc.nl

Abstract

OBJECTIVES:

This study was undertaken to develop a three-dimensional (3D) ultrasound method of measuring fetal brain volume.

STUDY DESIGN:

Serial 3D sonographic measurements of fetal brain volume were made in 68 normal singleton pregnancies at 18 to 34 weeks of gestation. A comparison was made with fetal brain volume estimates from two-dimensional (2D) sonographic measurement of head circumference and published postmortem fetal brain weights.

RESULTS:

Coefficient of variation for fetal brain volume (3D) caused by differences between repeated tests was 10.2% and between analyses of the same recorded volume 2.2%. Median brain volume increases from 34 mL at 18 weeks to 316 mL at 34 weeks. Median brain weight represented approximately 15% of total fetal weight. The 3D ultrasound-derived brain weight is larger than postmortem brain weight. However, this is not so for brain weight derived from total fetal weight at autopsy. A good agreement between 3D and 2D brain volume was found.

CONCLUSION:

Sonographic measurement of fetal brain volume demonstrated an acceptable intraobserver variability and a nearly 10-fold increase during the second half of gestation.

PMID:
14749673
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center