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Am J Obstet Gynecol. 2004 Jan;190(1):194-8.

Side-to-side differences in transcranial Doppler parameters in normotensive and preeclamptic pregnant women.

Author information

1
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA. asriskin@newmail.net

Abstract

OBJECTIVE:

This study was undertaken to investigate whether women with preeclampsia demonstrate larger side-to-side velocity differences in the middle cerebral artery (MCA) compared with normotensive pregnant women.

STUDY DESIGN:

Forty-one preeclamptic women and 50 normotensive pregnant women were studied during the third trimester. Transcranial Doppler ultrasound was used to measure peak, end-diastolic, and mean velocities in both MCAs. An asymmetry index was calculated as 100 x Rt-Lt//(Rt+Lt)/2, for each of the following parameters: mean velocity (Vm), pulsatility index (PI), and cerebral perfusion pressure (CPP). Student t test, Pearson correlation, and regression analysis were used. Significance was taken as P<.05.

RESULTS:

Both normotensive and preeclamptic pregnant women showed good correlation between Rt and Lt MCA Vm (R>0.8, P<.0001), PI (R>0.6, P.0001), and CPP (R>0.8, P<.0001). There were no differences in the asymmetry index for Vm, PI, or CPP between the two groups.

CONCLUSION:

Preeclampsia does not appear to induce greater side-to-side velocity differences in the MCA distribution.

PMID:
14749659
DOI:
10.1016/j.ajog.2003.07.005
[Indexed for MEDLINE]

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