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Respir Res. 2003 Dec 4;4:14. Print 2003.

Association studies for asthma and atopic diseases: a comprehensive review of the literature.

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1
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.

Abstract

Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.

PMID:
14748924
PMCID:
PMC314398
DOI:
10.1186/1465-9921-4-14
[Indexed for MEDLINE]
Free PMC Article
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