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Org Lett. 2004 Feb 5;6(3):385-8.

Model systems for flavoenzyme activity: interplay of hydrogen bonding and aromatic stacking in cofactor redox modulation.

Author information

1
Department of Chemistry, University of Massachusetts, Amherst 01003, USA.

Abstract

[structure: see text] A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and pi-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.

PMID:
14748599
DOI:
10.1021/ol036279g
[Indexed for MEDLINE]

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