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Hum Reprod. 2004 Feb;19(2):368-70.

Increased rates of thrombophilia in women with repeated IVF failures.

Author information

1
Department of Obstetrics and Gynecology, Lis Maternity Hospital and Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. azemf@tasmc.health.gov.il

Erratum in

  • Hum Reprod. 2004 May;19(5):1238. Ben Ami, Ido [added].

Abstract

BACKGROUND:

We investigated whether hereditary thrombophilia is more prevalent in women with recurrent IVF-embryo transfer failures.

METHODS:

This case-control study was conducted in an academic tertiary care hospital and compared 45 women with a history of four or more failed IVF cycles (group A) with 44 apparently healthy women matched for age and ethnic origin (group B). All participants were tested for inherited thrombophilias: mutations of prothrombin, factor V Leiden and methylene tetrahydrofolate reductase (MTHFR), and protein C, protein S and antithrombin III deficiencies.

RESULTS:

Excluding homozygotic MTHFR, the incidence of thrombophilia in group A, was 26.7% compared with 9.1% in group B (P = 0.003; odds ratio 2.9; 95% confidence interval 1.02-8.4). The incidence of thrombophilia in women with unexplained infertility in group A was 42.9% (9/21), compared with 18.2% in group B (P < 0.002).

CONCLUSIONS:

These data suggest that inherited thrombophilia may play a role in the aetiology of repeated IVF failures, particularly in the subgroup with unexplained fertility.

PMID:
14747183
DOI:
10.1093/humrep/deh069
[Indexed for MEDLINE]

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