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Nat Med. 2004 Feb;10(2):143-5. Epub 2004 Jan 25.

Differentiating the pathologies of cerebral malaria by postmortem parasite counts.

Author information

1
Department of Internal Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan 48824, USA. taylort@msu.edu

Erratum in

  • Nat Med. Nat Med. 2004 Apr;10(4):435. Mueller, Jeffrey G [corrected to Mueller, Jeffrey S].

Abstract

To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.

PMID:
14745442
DOI:
10.1038/nm986
[Indexed for MEDLINE]
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