Send to

Choose Destination
Nat Med. 2004 Feb;10(2):143-5. Epub 2004 Jan 25.

Differentiating the pathologies of cerebral malaria by postmortem parasite counts.

Author information

Department of Internal Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan 48824, USA.

Erratum in

  • Nat Med. Nat Med. 2004 Apr;10(4):435. Mueller, Jeffrey G [corrected to Mueller, Jeffrey S].


To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center