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Biosci Biotechnol Biochem. 2004 Jan;68(1):138-45.

Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages.

Author information

1
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan. kohnok@hayashibara.co.jp

Abstract

In this study, we have examined the anti-inflammatory actions of royal jelly (RJ) at a cytokine level. When supernatants of RJ suspensions were added to a culture of mouse peritoneal macrophages stimulated with lipopolysaccharide and IFN-gamma, the production of proinflammatory cytokines, such as TNF-alpha, IL-6, and IL-1, was efficiently inhibited in a dose-dependent manner without having cytotoxic effects on macrophages. This suggests that RJ contains factor(s) responsible for the suppression of proinflammatory cytokine secretion. We named the factor for honeybees RJ-derived anti-inflammatory factor (HBRJ-AIF), and further investigated the molecular aspects of it. Size fractionation study showed that HBRJ-AIF is composed of substances of low (< 5 kDa) and high (> 30 kDa) molecular weights, with the former being a major component. Chromatographic analysis showed that MRJP3 is one candidate for the HBRJ-AIF with high molecular weights. Thus, our results suggest that RJ has anti-inflammatory actions through inhibiting proinflammatory cytokine production by activated macrophages.

PMID:
14745176
DOI:
10.1271/bbb.68.138
[Indexed for MEDLINE]
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