Send to

Choose Destination
See comment in PubMed Commons below
Neurology. 2004 Jan 27;62(2):313-5.

Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD.

Author information

Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland.


The authors present a study on the association of PRNP and PRND gene polymorphisms with the occurrence and age at onset of Alzheimer's disease (AD). DNA from 79 Polish patients with probable AD and 107 healthy control subjects was studied. The PRNP codon 129 homozygosity seemed to be associated with the occurrence of AD: In AD patients, the percentage of Val/Val and Met/Met genotypes was higher than in the control subjects. A significant difference appeared also between early-onset (<70 years) and late-onset (> or = 70 years) AD patients in the PRND genotypes.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center