Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Res. 2004 Jan 15;64(2):452-5.

T-bet regulates metastasis rate in a murine model of primary prostate cancer.

Author information

1
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.

Abstract

The local progression of primary tumors is extrinsically controlled by type 1 immune responses, particularly via the cytokine IFN-gamma, whose secretion is highly dependent on helper T cells. The T-box transcription factor T-bet (Tbx21) plays a critical role in the development of type 1 helper T cells and is essential for the production of IFN-gamma. Here, the T-bet pathway in the autochthonous transgenic adenocarcinoma mouse prostate model is demonstrated to have only a modest effect on the characteristics of primary prostate cancers but rather exerts a significant suppressor function in the development of metastatic disease.

PMID:
14744755
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center