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Cell. 2004 Jan 23;116(2):299-311.

Unraveling V(D)J recombination; insights into gene regulation.

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Howard Hughes Medical Institute, The Children's Hospital, The CBR Institute for Biomedical Research, Inc., Harvard Medical School, Boston, MA 02115, USA.


V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports--the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.

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