Format

Send to

Choose Destination
Ann Pharmacother. 2004 Jan;38(1):146-50.

Antipyretic efficacy and safety of ibuprofen and acetaminophen in children.

Author information

1
Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. ran.goldman@sickkids.ca

Abstract

OBJECTIVE:

To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children.

DATA SOURCES:

Searches of MEDLINE (1966-November 2003) and EMBASE (1988-November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed.

DATA SYNTHESIS:

Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other.

CONCLUSIONS:

The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.

PMID:
14742809
DOI:
10.1345/aph.1C391
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center