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Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7.

Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738.

Author information

1
Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co Ltd, 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan. masae_sawada@po.fujisawa.co.jp

Abstract

The synthesis and biological properties of a novel squalene epoxidase inhibitor, FR194738, are described. This compound displayed potent in vitro inhibitory activities against squalene epoxidase and cholesterol synthesis, and lowered plasma cholesterol and triglyceride levels in dogs.

PMID:
14741258
DOI:
10.1016/j.bmcl.2003.11.072
[Indexed for MEDLINE]

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