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Biol Neonate. 2004;85(4):249-55. Epub 2004 Jan 21.

Hematological parameters and cobalamin status in infants born to smoking mothers.

Author information

1
Department of Pediatrics, University of Bergen, Bergen, Norway. albm@online.no

Abstract

Hematological parameters, serum cobalamin and folate levels, and the concentrations of the functional markers plasma methylmalonic acid and total homocysteine were determined in 173 newborns and 46 infants at 6 weeks to see whether maternal smoking influences the hematological parameters and the vitamin status of the newborn. At birth, there was a strong inverse correlation between the number of cigarettes smoked per day during pregnancy and red blood cell count (r = -0.56, p = 0.001) and hemoglobin level (r = -0.52, p = 0.003) in the newborns. Neonates born to smoking mothers had lower red blood cell counts and lower hemoglobin and serum cobalamin levels as compared with infants born to nonsmoking mothers. At 6 weeks, maternal smoking significantly predicted the methylmalonic acid and total homocysteine levels, suggesting an influence from smoking on the cobalamin function in these infants.

PMID:
14739552
DOI:
10.1159/000076362
[Indexed for MEDLINE]

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