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Immunity. 2004 Jan;20(1):2-4.

IL-6 trans-signaling: the heat is on.

Author information

1
Department of Biochemistry, Christian-Albrechts-Universit├Ąt zu Kiel, Olshausenstrasse 40, D-24098, Kiel, Germany.

Abstract

The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40 degrees C resulted in increased leukocyte adhesion to tissue sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-6R.

PMID:
14738759
[Indexed for MEDLINE]
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