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Curr Biol. 2004 Jan 20;14(2):R78-80.

Molecular chaperones: structure of a protein disaggregase.

Author information

1
1ZMBH, Universit├Ąt Heidelberg, Im Neuenheimer Feld 282, D-69120, Heidelberg, Germany. a.mogk@zmbh.uni-heidelberg.de

Abstract

The ring-forming molecular chaperone Hsp104/ClpB is a member of the AAA+ protein family which rescues proteins from aggregated states. The newly determined crystal structure of ClpB provides new insights into the mechanism of protein disaggregation, suggesting a crowbar activity mediated by a unique coiled-coil domain.

PMID:
14738756
[Indexed for MEDLINE]
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