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Curr Biol. 2004 Jan 20;14(2):R59-61.

Protein degradation: CUL-3 and BTB--partners in proteolysis.

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1
Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149, 13th St., Charlestown, Massachusetts 02129, USA. heuvel@helix.mgh.harvard.edu

Abstract

In early C. elegans embryos, the transition from meiosis to mitosis requires degradation of the MEI-1 protein. A novel class of SCF-like ubiquitin ligases has been identified that mediates this process. These ligases contain the CUL-3 scaffold at their core and use a BTB-domain protein in substrate recognition.

PMID:
14738749
[Indexed for MEDLINE]
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