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Food Chem Toxicol. 1992 Dec;30(12):1045-9.

Genotoxicity of 'gudakhu', a tobacco preparation. II. In habitual users.

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Environmental Mutagenesis Unit, School of Life Sciences, Sambalpur University, Orissa, India.


The genotoxic potential of 'gudakhu', a paste-like tobacco preparation that is used widely in Orissa, India, was evaluated using the micronucleus test in exfoliated cells of the buccal mucosa. Cells from 120 habitual users and from 102 non-users were examined. The incidence of micronuclei (MN) was increased in the mucosa cells of users, and the increase was significant in those who had used gudakhu for more than 5 yr. The increased incidence of MN was significantly correlated with the period of use of gudakhu, as well as with the frequency of daily use. There were no significant differences between the results for men and women.

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