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Br J Cancer. 2004 Jan 26;90(2):283-8.

Conferring specificity on the ubiquitous Raf/MEK signalling pathway.

Author information

1
Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK. e.oneill@beatson.gla.ac.uk

Abstract

The Raf-MEK-ERK signalling pathway controls fundamental cellular processes including proliferation, differentiation and survival. It remains enigmatic how this pathway can reliably convert a myriad of extracellular stimuli in specific biological responses. Recent results have shown that the Raf family isoforms A-Raf, B-Raf and Raf-1 have different physiological functions. Here we review how Raf isozyme diversity contributes to the specification of functional diversity, in particular regarding the role of Raf isozymes in cancer.

PMID:
14735164
PMCID:
PMC2409554
DOI:
10.1038/sj.bjc.6601488
[Indexed for MEDLINE]
Free PMC Article

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