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Curr Opin Immunol. 2004 Feb;16(1):108-13.

MHC class II signaling in antigen-presenting cells.

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Institut Universitaire d'Hématologie, IFR105, Hôpital Saint Louis AP-HP, 10 rue Claude Vellefaux, 75475 Paris, France.


The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their role as antigen-presenting structures; they are flexible receptors that, by triggering a variety of signaling pathways, can regulate APC activities from proliferation and maturation to apoptosis. Recent advances have provided insights into how these molecules might accommodate such regulation.

[Indexed for MEDLINE]

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