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Curr Opin Immunol. 2004 Feb;16(1):4-9.

Immunity in Caenorhabditis elegans.

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  • 1Institut National de la Sante et de la Recherche Medicale/Centre National pour la Recherche Scientifique /Université de la Méditerranée, 13288 Cedex 9 Marseille, France.


Until very recently it was not known whether the invertebrate Caenorhabditis elegans was capable of mounting a specific immune response to protect itself from pathogens. It has only just become clear that this simple nematode in fact possesses a complex innate immune system, involving multiple signalling pathways and an armoury of antimicrobial proteins and peptides. Genetic and microarray approaches are now revealing the molecular cross-talk that exists between the different signalling cascades.

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