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Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1075-80. Epub 2004 Jan 19.

Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein.

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1
Departments of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.

Abstract

Amyloid-beta peptide (Abeta) is central to the pathogenesis of Alzheimer's disease, and the low-density lipoprotein receptor-related protein (LRP) has been shown to alter Abeta metabolism in vitro. Here, we show that overexpression of a functional LRP minireceptor in the brain of PDAPP mice results in age-dependent increase of soluble brain Abeta, with no changes in Abeta plaque burden. Importantly, soluble brain Abeta was found to be primarily in the form of monomers/dimers and to be highly correlated with deficits in spatial learning and memory. These results provide in vivo evidence that LRP may contribute to memory deficits typical of Alzheimer's disease by modulating the pool of small soluble forms of Abeta.

PMID:
14732699
PMCID:
PMC327153
DOI:
10.1073/pnas.0305803101
[Indexed for MEDLINE]
Free PMC Article
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