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Trends Cell Biol. 1995 Apr;5(4):154-8.

VE-DIC light microscopy and the discovery of kinesin.

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Dept of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.


Major advances in science are often tightly coupled with the development of new technology. The discovery of kinesin is an excellent example of this principle. The new technology was video-enhanced differential interference contrast light microscopy, which provided the enormous gain in image contrast needed to detect and measure kinesin-based motility in living cells, cell extracts and in vitro motility assays.

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