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Trends Cell Biol. 1995 Oct;5(10):392-9.

Two tumour necrosis factor receptors: structure and function.

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Laboratory of Molecular Biology, Gent University and VIB, K L Ledeganckstraat 35, B-9000 Gent, Belgium.


Tumour necrosis factor (TNF) exerts two main effects: a beneficial one as an anti-infection, anti-tumour cytokine, and a detrimental one in the systemic inflammatory response syndrome (SIRS). Two receptors (TNF-R) mediate these effects, but their precise role in different cell types is far from solved. TNF induces receptor oligomerization, an event that is believed to connect the receptors to downstream signalling pathways. Recent research suggests that several TNF-R-associated proteins, including kinases, may initiate cytoplasmic signal transduction.

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