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Trends Cell Biol. 1995 Nov;5(11):413-6.

Mitotic disassembly of the mammalian Golgi apparatus.

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Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.


A cell-free system that mimics mitotic fragmentation of Golgi stacks has provided a working model for the disassembly process. Two distinct pathways, one COP-dependent and one COP-independent, act on Golgi stacks to give rise to two types of end products: transport vesicles and larger, more heterogeneous vesicles and tubules. We suggest that both mitotic end products result from enhanced fission of Golgi membranes under conditions where membrane fusion is generally inhibited.

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