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Trends Cell Biol. 1992 Oct;2(10):286-9.

Microtubule-bundling studies revisited: is there a role for MAPs?

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Center for Neurologic Diseases, Brigham and Women's Hospital, Program in Neurosciences, Harvard Medical School, Boston, MA 02115, USA.


The molecular mechanism of microtubule bundling has been enveloped in controversy for the past few years. At the centre of the debate are MAPs: are they necessary for the formation of microtubule bundles? In this article, Gloria Lee and Roland Brandt weigh the evidence and propose that microtubule stability might be the crucial factor in microtubule bundling. Perhaps then MAPs might act as spacer molecules between microtubules.

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