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Trends Cell Biol. 1994 Nov;4(11):399-403.

The Bcl-2 family of proteins: regulators of cell death and survival.

Author information

1
Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Abstract

The Bcl-2 protein inhibits apoptosis induced by a variety of signals, in a range of cell types and in diverse organisms, and it is implicated in both normal development and oncogenesis. Despite this central role, the mechanism of action of Bcl-2 is not yet clear. Recent studies have uncovered a number of Bcl-2-related gene products that regulate apoptosis either negatively or positively, and Bcl-2 forms heterodimers with at least one of these proteins, Bax. This article discusses the role of the Bcl-2 family of proteins in the light of these findings.

PMID:
14731816
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